83801. SCHOENLE, E. J.*, E. J. BOLTSHAUSER, S. BAEKKESKOV, M. LANDIN OLSSON, T. TORRESANI and A. VON FELTEN. (Univ. Children’s Hosp., Steinwiesstrasse 75, CH-8032 Zuerich, Switzerland.) DIABETOLOGIA 32 (6): 378-381. 1989.ą Preclinical and manifest diabetes mellitus in young patients with Friedreich’s ataxia: No evidence of immune process behind the islet cell destruction.— Friedreich’s ataxia is known to be associated with diabetes mellitus in up to 20% of the patients. However, type, development and course of diabetes mellitus are not well characterized. We report on 3 patients (2 female and 1 male, age 13-20 years) wi mellitus and (5) there was no remission. To evaluate a preclinical phase as in common autoimmune Type 1 diabetes, i.v. glucose tolerance tests (0.5 g glucose/kg body weight) were performed in 8 patients with Friedreich’s ataxia without diabetes mellitus. Seven patients had normal early phase insulin response. In contrast, the glucose disappearance rate was slow in 4 and normal in 3 patients. One of the 8 patients showed a prediabetic metabolic state: the early-phase insulin response was abolished and the glucose disappearance rate was abnormal. The results suggest that diabetes in Friedreich’s ataxia is caused by a loss of islet cells similar to common Type 1 diabetes but without HLA-association and without serologic evidence for autoimmune destruction of the islet cells.
Use the information in the record to select the one best answer to the following first seven questions. Review preceding sections of the tutorial to select the most correct answer to the remaining questions. When you finish the quiz, click "Submit Answers" to send your answers.
QuizMaker 2.0 for QuizServer © 1998 University of Hawaii. Developed for the University of Hawaii Office of Technology Transfer and Economic Development in cooperation with Maui Community College. All rights reserved. Any copying, distribution, or preparation of derivative works is strictly prohibited.