Some of the Longest Running Television Comedies

By number of seasons

27+  The Simpsons (Spring 2016)
19+  South Park (Fall 2015)
14  (The Adventures Of) Ozzie And Harriet, Family Guy (Spring 2016)
13  King Of The Hill
12  My Three Sons, Two And A Half Men
11  M*A*S*H, Cheers, The Danny Thomas Show / Make Room For Daddy, Happy Days, The Jeffersons, Married ... With Children, Frasier
10  Murphy Brown, Mystery Science Theater 3000, Friends
9  The Beverly Hillbillies, The Love Boat, Alice, Roseanne, Family Matters, Coach, All In The Family, One Day At A Time, Night Court, The Drew Carey Show, Everybody Loves Raymond, The King Of Queens, The Office

By number of episodes

583+ The Simpsons (Spring 2016)
435 (The Adventures Of) Ozzie & Harriet 
380 My Three Sons
336 The Danny Thomas Show / Make Room For Daddy
275 The Donna Reed Show, Cheers
274 The Beverly Hillbillies
267+ South Park (Fall 2015)
264 Frasier
262 Two And A Half Men
259 Married ... With Children
258+ Family Guy (Spring 2016)
257 King Of The Hill
256 M*A*S*H
255 Happy Days
253 The Jeffersons
252 Bewitched
249 The Andy Griffith Show
247 Murphy Brown
245 The Love Boat
238 Friends
234 Leave It To Beaver
233 The Drew Carey Show
222 Roseanne
214 Family Matters
210 All In The Family
209 One Day At A Time, The Facts Of Life, Everybody Loves Raymond
207 The King Of Queens
204 Home Improvement
202 Alice
201 The Cosby Show
200 Coach
199 The Office
193 Night Court, Will & Grace