Some of the Longest Running Television Comedies

By number of seasons

25+  The Simpsons (Spring 2014)
17+  South Park (Spring 2014)
14  (The Adventures Of) Ozzie And Harriet
13  King Of The Hill
12  My Three Sons, Family Guy (Spring 2014)
11  M*A*S*H, Cheers, The Danny Thomas Show / Make Room For Daddy, Happy Days, The Jeffersons, Married ... With Children, Frasier, Two And A Half Men (Spring 2014)
10  Murphy Brown, Mystery Science Theater 3000, Friends, Family Guy
9  The Beverly Hillbillies, The Love Boat, Alice, Roseanne, Family Matters, Coach, All In The Family, One Day At A Time, Night Court, The Drew Carey Show, Everybody Loves Raymond, The King Of Queens, The Office

By number of episodes
541+ The Simpsons (Spring 2014)
435 (The Adventures Of) Ozzie & Harriet 
380 My Three Sons
336 The Danny Thomas Show / Make Room For Daddy
275 The Donna Reed Show, Cheers
274 The Beverly Hillbillies
264 Frasier
259 Married ... With Children
257 King Of The Hill
256 M*A*S*H
255 Happy Days
253 The Jeffersons
252 Bewitched
249 The Andy Griffith Show
247 Murphy Brown, South Park (Spring 2014)
245 The Love Boat
239+ Two And A Half Men (Spring 2014)
238 Friends
234 Leave It To Beaver
233 The Drew Carey Show
222 Roseanne
221+ Family Guy (Spring 2014)
214 Family Matters
210 All In The Family
209 One Day At A Time, The Facts Of Life, Everybody Loves Raymond
207 The King Of Queens
204 Home Improvement
202 Alice
201 The Cosby Show
200 Coach
199 The Office
193 Night Court, Will & Grace